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Sleep

DSIP peptide reference

Nine-amino-acid peptide isolated from rabbit cerebral venous blood. Sleep modulation research.

Last reviewed May 6, 2026 Human data Not FDA approved
Peppi reviewing DSIP notes
Default dose label200 mcg
Preferred routeSubQ
Frequency label1× pre-bed
Storage window30 days mixed

Evidence snapshot

Human data

Evidence maturityHuman data
Animal and limited human studies; mixed clinical results

Research chemical (US)

Route map

How records are usually labeled

1 SubQ
2 IM
3 Intranasal

Rotate within abdomen.

Vial timeline

Storage cues to log

Before mixRefrigerate 2–8 °C; freeze long-term.
After mixRefrigerate 2–8 °C, use within 30 days.
Use-by cue30 days after mixing
Mixed vial window30 days
Use this as a record-keeping cue, not a replacement for product labeling.

Peppi workflow

From vial to review

Vial 5 mg vial
Dose 200 mcg
Route SubQ
Review 30d storage

Peppi turns scattered dose, vial, route, storage, note, and report details into one record trail.

Educational reference only

This page helps you understand what to track for DSIP. It is not medical advice, a prescription, or a recommendation to use this peptide. Discuss dose, route, timing, storage, and safety with a qualified healthcare professional.

Overview

DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide isolated in 1977 from the cerebral venous blood of rabbits during electrically induced sleep. It crosses the blood-brain barrier and has been studied for sleep architecture modulation, stress response, and ACTH/cortisol regulation. Subjective sleep effects in humans are inconsistent across studies.

Also known as: Delta Sleep-Inducing Peptide.

Sleep architecture researchStress and circadian disruption recoveryWithdrawal-related sleep disturbance research

Mechanism and timing snapshot

Crosses blood-brain barrier; modulates delta-wave sleep, ACTH and cortisol secretion, and shows broad neuroregulatory activity. Specific receptor not definitively identified.

Onset label15 min
Catalog onset field, when available.
Half-life label18 min
Plasma half-life ~7–15 min; biological effects persist longer
Duration label8 hr
Catalog duration field, when available.
subQ High
IM High
intranasal Moderate
oral Negligible

Tracking defaults

These values come from Peppi's catalog so records can be prefilled consistently. They should be reviewed against your clinician's instructions before logging real-world use.

Catalog default dose200 mcg
Catalog dose range100 mcg - 1 mg
Default routeSubQ
Frequency label1× pre-bed
Best time label30–60 min before sleep.
Food noteNone significant.

Catalog protocol note

100–500 mcg subQ 30–60 min before bed for 5–10 nights.

Routes and site notes

Available route labelsSubQ, IM, Intranasal
Preferred route labelSubQ
Common site labelsAbdomen
Site rotation noteRotate within abdomen.

Chemistry

SequenceTrp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Amino acids9
Molecular formulaC35H48N10O15
Molecular weight848.81 Da

Vial, reconstitution, and storage

Supply formLyophilized powder
Typical vial size5 mg
DiluentBacteriostatic water
Diluent volume2.5 mL
Concentration note5 mg in 2.5 mL → 0.10 mL = 200 mcg (10 units on a 100-unit insulin syringe).
Before reconstitutionRefrigerate 2–8 °C; freeze long-term.
After reconstitutionRefrigerate 2–8 °C, use within 30 days.
Reconstituted shelf life30 days
Light sensitiveYes
Freeze/thaw warningYes

Safety notes

Common and rare side effects listed in the catalog

  • Generally well-tolerated
  • Mild morning grogginess (variable)
  • Headache
  • Vivid dreams

Contraindications and warnings

  • Pregnancy
  • Not FDA-approved.
  • Subjective sleep response varies widely between users.

Other considerations

  • Effect is not sedating — subjective improvement in sleep quality varies.
  • Best as a short course rather than a long-term sleep aid.

Evidence and regulatory context

Evidence levelAnimal and limited human studies; mixed clinical results
FDA approvedNo
Regulatory statusResearch chemical (US)
Prescription requiredNo
Approved countriesNot listed

Stacking and cycle notes

Stacks well withNot listed
Avoid combining noteStrong sedatives without clinician oversight
Typical cycle label1–2
Typical break label2+
Cycle guidanceShort courses; not designed for chronic nightly use.

Tracking tips

  • Set realistic expectations — clinical sleep data is mixed.
  • Don't combine with strong sedatives without clinician input.
  • Short courses (5–10 nights) are typical, not chronic use.

References

Track it in Peppi

Keep DSIP records organized.

Use Peppi for dose logs, vial inventory, storage dates, reminders, journal notes, photos, and clinician-ready reports.

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FAQ

What should I track for DSIP?

Track the peptide name, dose amount and unit, route, vial label, timing, reconstitution or expiration dates, storage notes, and any symptoms or questions for clinician review.

Does Peppi tell me how to use DSIP?

No. Peppi organizes educational reference and your own records. Protocol decisions should come from a qualified healthcare professional.

Can I export DSIP records?

Peppi is designed to keep dose logs, vial inventory, journal notes, and reports easier to review and export.

Last reviewed: May 6, 2026