PeppiLibrary

Skin & Anti-aging

Eyeseryl peptide reference

Topical tetrapeptide for under-eye puffiness and dark circles.

Last reviewed May 6, 2026 FDA-approved FDA approved
Peppi reviewing Eyeseryl notes
Default dose labelNot listed
Preferred routeTopical
Frequency label1–2× daily
Storage windowNot listed

Evidence snapshot

FDA-approved

Evidence maturityFDA approved
Cosmetic ingredient with manufacturer-funded dermatology studies

FDA-approved cosmetic ingredient

Route map

How records are usually labeled

1 Topical

Apply gently with ring finger; avoid rubbing thin under-eye skin.

Vial timeline

Storage cues to log

Before mixPer product label — typically room temperature.
After mixN/A
Use-by cueShelf life not listed
Mixed vial windowNot listed
Use this as a record-keeping cue, not a replacement for product labeling.

Peppi workflow

From vial to review

Vial label
Dose Not listed
Route Topical
Review storage

Peppi turns scattered dose, vial, route, storage, note, and report details into one record trail.

Educational reference only

This page helps you understand what to track for Eyeseryl. It is not medical advice, a prescription, or a recommendation to use this peptide. Discuss dose, route, timing, storage, and safety with a qualified healthcare professional.

Overview

Eyeseryl is a synthetic 4-amino-acid peptide developed by Lipotec, marketed for cosmetic improvement of the under-eye area. It is reported to inhibit non-enzymatic glycation of collagen, reducing skin permeability changes that contribute to fluid accumulation and dark circles. Most studied in topical eye-area formulations.

Also known as: Acetyl Tetrapeptide-5.

Under-eye puffiness reductionDark circle improvement (modest)Periocular skin elasticity

Mechanism and timing snapshot

Inhibits glycation of dermal collagen, restoring elasticity and reducing capillary permeability changes that drive periocular fluid retention. Local action; minimal systemic absorption.

Onset labelNot listed
Catalog onset field, when available.
Half-life labelNot listed
Topical; locally active
Duration label12 hr
Catalog duration field, when available.
topical Moderate; designed for periocular skin penetration

Tracking defaults

These values come from Peppi's catalog so records can be prefilled consistently. They should be reviewed against your clinician's instructions before logging real-world use.

Catalog default doseNot listed
Catalog dose rangeNot listed - Not listed
Default routeTopical
Frequency label1–2× daily
Best time labelMorning before makeup; evening as last skincare step.
Food noteN/A — topical.

Catalog protocol note

1–2% concentration eye serum applied AM and PM to under-eye area for 4–8 weeks before judging.

Routes and site notes

Available route labelsTopical
Preferred route labelTopical
Common site labelsUnder-eye area
Site rotation noteApply gently with ring finger; avoid rubbing thin under-eye skin.

Chemistry

SequenceAc-Ala-His-Ser-His-NH2
Amino acids4
Molecular formulaC20H30N8O7
Molecular weight494.51 Da

Vial, reconstitution, and storage

Supply formPre-formulated eye serum or cream
Typical vial sizeNot listed
DiluentN/A
Diluent volumeNot listed
Concentration note1–2% concentration in well-formulated eye-area base.
Before reconstitutionPer product label — typically room temperature.
After reconstitutionN/A
Reconstituted shelf lifeNot listed
Light sensitiveNo
Freeze/thaw warningNo

Safety notes

Common and rare side effects listed in the catalog

  • Generally extremely well-tolerated topically
  • Mild irritation (formulation-dependent)
  • Stinging if applied near eye margin

Contraindications and warnings

  • Active eye infection or dermatitis in application area
  • Avoid contact with eye surface — apply to skin only.

Other considerations

  • Effects on puffiness are modest — set realistic expectations.
  • Pairs with caffeine, niacinamide, and retinol in layered eye-care routines.
  • Consistent multi-month use is required for visible change.

Evidence and regulatory context

Evidence levelCosmetic ingredient with manufacturer-funded dermatology studies
FDA approvedYes
Regulatory statusFDA-approved cosmetic ingredient
Prescription requiredNo
Approved countriesUS, EU, and most others

Stacking and cycle notes

Stacks well withargireline, matrixyl
Avoid combining noteNot listed
Typical cycle labelongoing
Typical break labelNot typically cycled
Cycle guidanceContinuous topical use; results regress on discontinuation.

Tracking tips

  • Apply with the ring finger — under-eye skin is delicate.
  • Pairs with caffeine and niacinamide in layered eye-care routines.
  • Allow 4–8 weeks before judging — improvements are gradual.

References

Track it in Peppi

Keep Eyeseryl records organized.

Use Peppi for dose logs, vial inventory, storage dates, reminders, journal notes, photos, and clinician-ready reports.

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FAQ

What should I track for Eyeseryl?

Track the peptide name, dose amount and unit, route, vial label, timing, reconstitution or expiration dates, storage notes, and any symptoms or questions for clinician review.

Does Peppi tell me how to use Eyeseryl?

No. Peppi organizes educational reference and your own records. Protocol decisions should come from a qualified healthcare professional.

Can I export Eyeseryl records?

Peppi is designed to keep dose logs, vial inventory, journal notes, and reports easier to review and export.

Last reviewed: May 6, 2026