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Sexual Health

Kisspeptin-10 peptide reference

C-terminal fragment of kisspeptin. Master regulator of the HPG axis. Stimulates LH/FSH.

Last reviewed May 6, 2026 Human data Not FDA approved
Peppi reviewing Kisspeptin-10 notes
Default dose label100 mcg
Preferred routeSubQ
Frequency labelMultiple times daily for pulsatile effect
Storage window21 days mixed

Evidence snapshot

Human data

Evidence maturityHuman data
Multiple Phase 1/2 clinical trials; not yet approved

Investigational / research chemical

Route map

How records are usually labeled

1 SubQ
2 IV

Rotate within abdomen if pulsatile dosing.

Vial timeline

Storage cues to log

Before mixRefrigerate 2–8 °C; freeze long-term.
After mixRefrigerate 2–8 °C, use within 14–21 days.
Use-by cue21 days after mixing
Mixed vial window21 days
Use this as a record-keeping cue, not a replacement for product labeling.

Peppi workflow

From vial to review

Vial 1 mg vial
Dose 100 mcg
Route SubQ
Review 21d storage

Peppi turns scattered dose, vial, route, storage, note, and report details into one record trail.

Educational reference only

This page helps you understand what to track for Kisspeptin-10. It is not medical advice, a prescription, or a recommendation to use this peptide. Discuss dose, route, timing, storage, and safety with a qualified healthcare professional.

Overview

Kisspeptin-10 is the active 10-amino-acid C-terminal fragment of the longer kisspeptin protein. Kisspeptin neurons in the hypothalamus are the master regulators of GnRH release — and therefore of LH, FSH, testosterone, and estrogen. Synthetic KP-10 is researched for hypogonadism, pulsatile HPG axis stimulation, and as an alternative to gonadorelin/HCG.

Also known as: KP-10, Metastin(45-54).

Hypogonadotropic hypogonadism researchPost-cycle therapy alternative (research)Fertility research (ovulation induction)

Mechanism and timing snapshot

Binds GPR54 (KISS1R) on hypothalamic GnRH neurons, stimulating GnRH release in pulsatile fashion. This drives downstream LH and FSH secretion from the pituitary, raising endogenous testosterone (males) or estradiol (females).

Onset label5 min
Catalog onset field, when available.
Half-life label4 min
Plasma half-life ~4 minutes; effects on LH measurable for 30–60 min
Duration label1 hr
Catalog duration field, when available.
subQ Moderate
IV High
oral Negligible

Tracking defaults

These values come from Peppi's catalog so records can be prefilled consistently. They should be reviewed against your clinician's instructions before logging real-world use.

Catalog default dose100 mcg
Catalog dose range50 mcg - 1 mg
Default routeSubQ
Frequency labelMultiple times daily for pulsatile effect
Best time labelMultiple pulses across the day for LH stimulation.
Food noteNone.

Catalog protocol note

Research protocols vary widely (50 mcg–1 mg). Pulsatile dosing every 1–2 hours mimics natural release.

Routes and site notes

Available route labelsSubQ, IV
Preferred route labelSubQ
Common site labelsAbdomen
Site rotation noteRotate within abdomen if pulsatile dosing.

Chemistry

SequenceTyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Amino acids10
Molecular formulaC63H83N17O14
Molecular weight1302.45 Da

Vial, reconstitution, and storage

Supply formLyophilized powder
Typical vial size1 mg
DiluentBacteriostatic water
Diluent volume1 mL
Concentration note1 mg in 1 mL → 0.10 mL = 100 mcg (10 units on a 100-unit insulin syringe).
Before reconstitutionRefrigerate 2–8 °C; freeze long-term.
After reconstitutionRefrigerate 2–8 °C, use within 14–21 days.
Reconstituted shelf life21 days
Light sensitiveYes
Freeze/thaw warningYes

Safety notes

Common and rare side effects listed in the catalog

  • Generally well-tolerated
  • Mild flushing
  • Headache
  • Transient blood pressure changes

Contraindications and warnings

  • Active hormone-sensitive malignancy
  • Pregnancy
  • Not FDA-approved.
  • Effects on long-term HPG axis with chronic use are poorly characterised.

Other considerations

  • Mechanism is upstream of HCG/Gonadorelin — stimulates the natural pulse generator.
  • Pulsatile dosing matters more than total daily dose for HPG axis effect.
  • Not a quick libido fix — works by raising endogenous testosterone over weeks.

Evidence and regulatory context

Evidence levelMultiple Phase 1/2 clinical trials; not yet approved
FDA approvedNo
Regulatory statusInvestigational / research chemical
Prescription requiredNo
Approved countriesNot listed

Stacking and cycle notes

Stacks well withNot listed
Avoid combining noteGnRH antagonists, Aromatase inhibitors without monitoring
Typical cycle label4–8
Typical break label4
Cycle guidanceShort cycles to assess HPG axis response. Discuss with an endocrinologist for clinical use.

Tracking tips

  • Pulsatile dosing matters — single daily injection misses the natural rhythm.
  • Get baseline LH/FSH/testosterone bloodwork before starting.
  • Consult an endocrinologist before using for hormonal indications.

References

Track it in Peppi

Keep Kisspeptin-10 records organized.

Use Peppi for dose logs, vial inventory, storage dates, reminders, journal notes, photos, and clinician-ready reports.

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FAQ

What should I track for Kisspeptin-10?

Track the peptide name, dose amount and unit, route, vial label, timing, reconstitution or expiration dates, storage notes, and any symptoms or questions for clinician review.

Does Peppi tell me how to use Kisspeptin-10?

No. Peppi organizes educational reference and your own records. Protocol decisions should come from a qualified healthcare professional.

Can I export Kisspeptin-10 records?

Peppi is designed to keep dose logs, vial inventory, journal notes, and reports easier to review and export.

Last reviewed: May 6, 2026