PeppiLibrary

Growth Hormone

MGF peptide reference

Local IGF-1 splice variant produced by mechanically loaded muscle. Activates satellite cells.

Last reviewed May 6, 2026 Human data Not FDA approved
Peppi reviewing MGF notes
Default dose label200 mcg
Preferred routeIM (near worked muscle)
Frequency labelPEG-MGF: 1–3× weekly. Native MGF: post-workout daily.
Storage window21 days mixed

Evidence snapshot

Human data

Evidence maturityHuman data
Animal studies; very limited human data

Research chemical (US) / WADA-prohibited

Route map

How records are usually labeled

1 IM
2 SubQ

Inject into or adjacent to the muscle group trained that session.

Vial timeline

Storage cues to log

Before mixRefrigerate 2–8 °C; freeze long-term.
After mixRefrigerate 2–8 °C, use within 14–21 days.
Use-by cue21 days after mixing
Mixed vial window21 days
Use this as a record-keeping cue, not a replacement for product labeling.

Peppi workflow

From vial to review

Vial 2 mg vial
Dose 200 mcg
Route IM (near worked muscle)
Review 21d storage

Peppi turns scattered dose, vial, route, storage, note, and report details into one record trail.

Educational reference only

This page helps you understand what to track for MGF. It is not medical advice, a prescription, or a recommendation to use this peptide. Discuss dose, route, timing, storage, and safety with a qualified healthcare professional.

Overview

MGF (Mechano Growth Factor) is a splice variant of IGF-1 expressed locally in skeletal muscle following mechanical loading or damage. The synthetic peptide includes a unique 24-amino-acid C-terminal extension absent in systemic IGF-1, giving it distinct receptor-binding behavior. PEGylated MGF (PEG-MGF) extends the very short native half-life for practical injection.

Also known as: Mechano Growth Factor, IGF-1Ec.

Localised muscle repairRecovery from training-induced damageHypertrophy adjunct

Mechanism and timing snapshot

Activates muscle satellite cells (myoblast proliferation) without strongly stimulating differentiation; promotes localised muscle repair after damage. Native peptide has very short half-life; PEGylation extends to days.

Onset labelNot listed
Catalog onset field, when available.
Half-life label48 hr
Native MGF: ~5–7 minutes. PEG-MGF: ~48–72 hours.
Duration label72 hr
Catalog duration field, when available.
subQ Moderate (PEG-MGF)
IM High (PEG-MGF, often injected near worked muscle)
oral Negligible

Tracking defaults

These values come from Peppi's catalog so records can be prefilled consistently. They should be reviewed against your clinician's instructions before logging real-world use.

Catalog default dose200 mcg
Catalog dose range100 mcg - 400 mcg
Default routeIM
Frequency labelPEG-MGF: 1–3× weekly. Native MGF: post-workout daily.
Best time labelWithin 60 min after intense training when satellite cells are most receptive.
Food noteNone.

Catalog protocol note

PEG-MGF: 200 mcg IM/subQ near worked muscle 2× weekly post-training, for 4–6 weeks.

Routes and site notes

Available route labelsIM, SubQ
Preferred route labelIM (near worked muscle)
Common site labelsWorked muscle (e.g., bicep, quad)
Site rotation noteInject into or adjacent to the muscle group trained that session.

Chemistry

SequenceModified IGF-1 with unique 24-AA E-domain extension
Amino acids24
Molecular formulaNot listed
Molecular weight2867 Da

Vial, reconstitution, and storage

Supply formLyophilized powder
Typical vial size2 mg
DiluentBacteriostatic water
Diluent volume2 mL
Concentration note2 mg in 2 mL → 0.20 mL = 200 mcg (20 units on a 100-unit insulin syringe).
Before reconstitutionRefrigerate 2–8 °C; freeze long-term.
After reconstitutionRefrigerate 2–8 °C, use within 14–21 days.
Reconstituted shelf life21 days
Light sensitiveYes
Freeze/thaw warningYes

Safety notes

Common and rare side effects listed in the catalog

  • Generally well-tolerated
  • Localised soreness at injection site
  • Mild hypoglycemia (less than IGF-1 LR3)
  • Joint stiffness

Contraindications and warnings

  • Active malignancy (theoretical)
  • Pregnancy
  • Not FDA-approved.
  • WADA-prohibited — banned in competitive sports.

Other considerations

  • Best dosed post-workout to coincide with natural satellite cell activation.
  • Less hypoglycemia risk than IGF-1 LR3.
  • Localised injection is the differentiator — systemic dosing wastes the local-action mechanism.

Evidence and regulatory context

Evidence levelAnimal studies; very limited human data
FDA approvedNo
Regulatory statusResearch chemical (US) / WADA-prohibited
Prescription requiredNo
Approved countriesNot listed

Stacking and cycle notes

Stacks well withcjc-1295, ipamorelin
Avoid combining noteigf-1-lr3 (redundant + amplified hypo risk)
Typical cycle label4–6
Typical break label4
Cycle guidanceShort cycles aligned with training blocks.

Tracking tips

  • Inject near the muscle you just trained — local action is the entire premise.
  • PEG-MGF (PEGylated) is what you want for practical dosing; native MGF half-life is too short.
  • Banned by WADA — disqualifying in competitive sports.

References

Track it in Peppi

Keep MGF records organized.

Use Peppi for dose logs, vial inventory, storage dates, reminders, journal notes, photos, and clinician-ready reports.

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FAQ

What should I track for MGF?

Track the peptide name, dose amount and unit, route, vial label, timing, reconstitution or expiration dates, storage notes, and any symptoms or questions for clinician review.

Does Peppi tell me how to use MGF?

No. Peppi organizes educational reference and your own records. Protocol decisions should come from a qualified healthcare professional.

Can I export MGF records?

Peppi is designed to keep dose logs, vial inventory, journal notes, and reports easier to review and export.

Last reviewed: May 6, 2026