PeppiLibrary

Anti-aging

Epitalon peptide reference

Tetrapeptide researched by Khavinson lab for telomerase activation and circadian regulation.

Last reviewed May 6, 2026 Preclinical Not FDA approved
Peppi reviewing Epitalon notes
Default dose label10 mg
Preferred routeSubQ
Frequency labelDaily during course
Storage window30 days mixed

Evidence snapshot

Preclinical

Evidence maturityPreclinical
Russian clinical and animal research; very limited Western replication

Research chemical (US/EU)

Route map

How records are usually labeled

1 SubQ
2 Intranasal

Rotate within abdomen.

Vial timeline

Storage cues to log

Before mixRefrigerate 2–8 °C; freeze long-term.
After mixRefrigerate 2–8 °C, use within 30 days.
Use-by cue30 days after mixing
Mixed vial window30 days
Use this as a record-keeping cue, not a replacement for product labeling.

Peppi workflow

From vial to review

Vial 50 mg vial
Dose 10 mg
Route SubQ
Review 30d storage

Peppi turns scattered dose, vial, route, storage, note, and report details into one record trail.

Educational reference only

This page helps you understand what to track for Epitalon. It is not medical advice, a prescription, or a recommendation to use this peptide. Discuss dose, route, timing, storage, and safety with a qualified healthcare professional.

Overview

Epitalon is a synthetic 4-amino-acid peptide developed by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. Russian research has reported telomerase activation, melatonin normalisation, and lifespan extension in animal models. Western clinical validation is limited; sold as research-only in the US.

Also known as: Epithalon, Epithalamin.

Anti-aging researchSleep and melatonin regulationTelomere research

Mechanism and timing snapshot

Reported to upregulate telomerase activity, normalise pineal melatonin secretion, and modulate gene expression related to cell-cycle regulation. Mechanism not fully characterised in Western literature.

Onset labelNot listed
Catalog onset field, when available.
Half-life label30 min
Plasma half-life minutes; effects on transcription persist longer
Duration labelNot listed
Catalog duration field, when available.
subQ Moderate
intranasal Moderate
oral Low

Tracking defaults

These values come from Peppi's catalog so records can be prefilled consistently. They should be reviewed against your clinician's instructions before logging real-world use.

Catalog default dose10 mg
Catalog dose range5 mg - 10 mg
Default routeSubQ
Frequency labelDaily during course
Best time labelEvening (aligns with pineal/melatonin pathway).
Food noteNone.

Catalog protocol note

5–10 mg subQ daily for 10–20 days, repeated every 6 months (Khavinson protocol).

Routes and site notes

Available route labelsSubQ, Intranasal
Preferred route labelSubQ
Common site labelsAbdomen
Site rotation noteRotate within abdomen.

Chemistry

SequenceAla-Glu-Asp-Gly
Amino acids4
Molecular formulaC14H22N4O9
Molecular weight390.35 Da

Vial, reconstitution, and storage

Supply formLyophilized powder
Typical vial size50 mg
DiluentBacteriostatic water
Diluent volume5 mL
Concentration note50 mg in 5 mL → 1.0 mL = 10 mg (100 units on a 100-unit insulin syringe).
Before reconstitutionRefrigerate 2–8 °C; freeze long-term.
After reconstitutionRefrigerate 2–8 °C, use within 30 days.
Reconstituted shelf life30 days
Light sensitiveYes
Freeze/thaw warningYes

Safety notes

Common and rare side effects listed in the catalog

  • Generally well-tolerated; rare reports of mild fatigue
  • Mild headache
  • Local injection-site reactions

Contraindications and warnings

  • Pregnancy
  • Active malignancy (theoretical — telomerase activation)
  • Western clinical evidence is limited; most data is from a single Russian research group.

Other considerations

  • Take Khavinson's results with appropriate skepticism — limited Western replication.
  • Long-term safety in humans is poorly characterised.

Evidence and regulatory context

Evidence levelRussian clinical and animal research; very limited Western replication
FDA approvedNo
Regulatory statusResearch chemical (US/EU)
Prescription requiredNo
Approved countriesNot listed

Stacking and cycle notes

Stacks well withNot listed
Avoid combining noteNot listed
Typical cycle label2–3 (course)
Typical break label24 (6 months)
Cycle guidanceKhavinson protocol: 10–20 day courses repeated every 6 months.

Tracking tips

  • Course-based dosing (10–20 days, then long break) is the published protocol.
  • Healthy skepticism is warranted — most positive data is from one research group.
  • Discuss with a clinician if you have any cancer history.

References

Track it in Peppi

Keep Epitalon records organized.

Use Peppi for dose logs, vial inventory, storage dates, reminders, journal notes, photos, and clinician-ready reports.

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FAQ

What should I track for Epitalon?

Track the peptide name, dose amount and unit, route, vial label, timing, reconstitution or expiration dates, storage notes, and any symptoms or questions for clinician review.

Does Peppi tell me how to use Epitalon?

No. Peppi organizes educational reference and your own records. Protocol decisions should come from a qualified healthcare professional.

Can I export Epitalon records?

Peppi is designed to keep dose logs, vial inventory, journal notes, and reports easier to review and export.

Last reviewed: May 6, 2026