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Sexual Health

Triptorelin peptide reference

Long-acting GnRH agonist. Initial flare then sustained HPG suppression.

Last reviewed May 6, 2026 FDA-approved FDA approved
Peppi reviewing Triptorelin notes
Default dose label100 mcg
Preferred routeSubQ (research) / IM (depot)
Frequency labelDaily 100 mcg (research), or depot every 1/3/6 months
Storage window28 days mixed

Evidence snapshot

FDA-approved

Evidence maturityFDA approved
FDA-approved (Trelstar) for advanced prostate cancer; international approvals for other indications

Prescription medication

Route map

How records are usually labeled

1 SubQ
2 IM

Rotate sites for repeated daily dosing.

Vial timeline

Storage cues to log

Before mixRefrigerate 2–8 °C.
After mixRefrigerate 2–8 °C, use within 28 days (research). Depot single-use.
Use-by cue28 days after mixing
Mixed vial window28 days
Use this as a record-keeping cue, not a replacement for product labeling.

Peppi workflow

From vial to review

Vial 2 mg vial
Dose 100 mcg
Route SubQ (research) / IM (depot)
Review 28d storage

Peppi turns scattered dose, vial, route, storage, note, and report details into one record trail.

Educational reference only

This page helps you understand what to track for Triptorelin. It is not medical advice, a prescription, or a recommendation to use this peptide. Discuss dose, route, timing, storage, and safety with a qualified healthcare professional.

Overview

Triptorelin is a synthetic 10-amino-acid GnRH analog with D-tryptophan substitution at position 6, dramatically extending its half-life vs native gonadorelin. After an initial 1–2 week LH/testosterone surge ('flare'), continuous receptor stimulation downregulates GnRH receptors, suppressing the HPG axis. FDA-approved as Trelstar for advanced prostate cancer; widely used internationally for endometriosis, central precocious puberty, and fertility cycles.

Also known as: Trelstar, Decapeptyl, Diphereline.

Advanced prostate cancer (FDA: Trelstar)Central precocious pubertyEndometriosis hormone suppressionFertility cycle protocols (off-label)Post-cycle therapy research (off-label, low dose)

Mechanism and timing snapshot

GnRH-receptor agonist with extended half-life. Initial overstimulation produces a testosterone/estrogen surge; chronic exposure downregulates GnRH receptors, ablating endogenous LH/FSH and gonadal steroid synthesis.

Onset labelNot listed
Catalog onset field, when available.
Half-life label3 hr
Plasma half-life ~3 h; depot formulations release over 1–6 months
Duration label4320 hr
Catalog duration field, when available.
subQ High
IM High
depot Sustained release 1–6 months

Tracking defaults

These values come from Peppi's catalog so records can be prefilled consistently. They should be reviewed against your clinician's instructions before logging real-world use.

Catalog default dose100 mcg
Catalog dose range100 mcg - 11.25 mg
Default routeSubQ
Frequency labelDaily 100 mcg (research), or depot every 1/3/6 months
Best time labelSame time each day for daily use; on schedule for depot.
Food noteNone.

Catalog protocol note

Acute use (post-cycle therapy research): 100 mcg subQ for 7–10 days. Clinical depot: 3.75 mg IM monthly or 11.25 mg every 3 months.

Routes and site notes

Available route labelsSubQ, IM
Preferred route labelSubQ (research) / IM (depot)
Common site labelsAbdomen, Glute (depot IM)
Site rotation noteRotate sites for repeated daily dosing.

Chemistry

SequencepGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
Amino acids10
Molecular formulaC64H82N18O13
Molecular weight1311.45 Da

Vial, reconstitution, and storage

Supply formLyophilized powder (research) OR pre-formulated depot suspension (clinical)
Typical vial size2 mg
DiluentBacteriostatic water (research powder)
Diluent volume2 mL
Concentration noteResearch 2 mg in 2 mL → 0.10 mL = 100 mcg. Depot is single-use pre-mixed suspension.
Before reconstitutionRefrigerate 2–8 °C.
After reconstitutionRefrigerate 2–8 °C, use within 28 days (research). Depot single-use.
Reconstituted shelf life28 days
Light sensitiveYes
Freeze/thaw warningYes

Safety notes

Common and rare side effects listed in the catalog

  • Initial 'flare' — temporary symptom worsening in cancer patients
  • Hot flashes
  • Decreased libido (chronic use)
  • Injection-site reactions
  • Bone density loss (long-term)
  • Mood changes
  • Glucose intolerance

Contraindications and warnings

  • Pregnancy
  • Hypersensitivity to GnRH analogs
  • Initial flare can worsen prostate cancer symptoms — co-administer antiandrogen for first 2–4 weeks per oncology protocols.
  • Long-term suppression risks bone loss — monitor.

Other considerations

  • Used in PCT research at much lower doses than oncology depots — verify protocol carefully.
  • Acute short-course use is for HPG axis 'restart' research; long-term depots are for clinical hormone-suppression indications.
  • Effects after stopping take weeks to recover.

Evidence and regulatory context

Evidence levelFDA-approved (Trelstar) for advanced prostate cancer; international approvals for other indications
FDA approvedYes
Regulatory statusPrescription medication
Prescription requiredYes
Approved countriesUS, EU, UK, and many others

Stacking and cycle notes

Stacks well withNot listed
Avoid combining noteGnRH antagonists
Typical cycle label1–2 (acute restart) or ongoing (clinical depot)
Typical break labelPer protocol
Cycle guidanceAcute use: 7–10 days. Chronic clinical use: continuous per indication.

Tracking tips

  • Acute single-dose research use is very different from clinical depot use — don't confuse the two.
  • Initial 'flare' response peaks at days 5–10 with testosterone surge.
  • Verify with prescriber before any HPG-axis intervention if you're on TRT or fertility-relevant hormones.

References

Track it in Peppi

Keep Triptorelin records organized.

Use Peppi for dose logs, vial inventory, storage dates, reminders, journal notes, photos, and clinician-ready reports.

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FAQ

What should I track for Triptorelin?

Track the peptide name, dose amount and unit, route, vial label, timing, reconstitution or expiration dates, storage notes, and any symptoms or questions for clinician review.

Does Peppi tell me how to use Triptorelin?

No. Peppi organizes educational reference and your own records. Protocol decisions should come from a qualified healthcare professional.

Can I export Triptorelin records?

Peppi is designed to keep dose logs, vial inventory, journal notes, and reports easier to review and export.

Last reviewed: May 6, 2026